National Taiwan University, Center of Innovation and Synergy for Intelligent Home and Living Technology

Postdoctoral Researcher | September 2018

Massachusetts General Hospital, Laboratory of Computer Science

Research Scholar | September 2017 – August 2018

• Design a risk model to link diagnosis, medical treatment and outcome based on MGH Epic EHR system and MIMIC database.
• Develop a cognitive aid for clinicians to identify patients at risk of missed or delayed diagnosis, leveraging artificial intelligence technology including natural language processing.

KPMG, Financial Risk Management

Assistant Manager | August 2015 – August 2017

• Design Asset-Liability-Risk management system, including the spec of a complete data warehouse, ETL, batch and web-based graphic interface, coordinating with Risk-IT teams, financial engineers, and financial managers.
• Lead finance product valuation team, providing valuation services to clients, developing valuation tools, assisting our company’s audit team.
•  Played key roles in FRM for developing new projects for future use.
•  Managed projects with customers’ high satisfaction.

MIT, Department of Civil and Environmental Engineering

Research Assistant | September 2010 – June 2015

Advisor: Markus Buehler

•   Developed multiscale and theoretical model to link the atomistic chemical structure and macroscopic properties of trichocyte keratin protein, and investigating the mutability of Nvjp-1 protein in various environments using molecular dynamics simulation.
•  Completed the first full-atomistic model for trichocyte keratin protein and validated the geometrical properties against experimental data. Results of mechanical testing suggested the trichocyte keratin has a higher durability and resistibility against the external loading in the presence of disulfide cross-link.
•  Investigated the mutability of Nvjp-1 protein with metal-coordination bonds in the varied chemical environments from the single molecule level to a larger length scale. Nvjp-1 forms a more compact structure and metal-coordination in the presence of Zn ions and at a higher pH at the single molecular level. At the mesoscale level, the effect of pH leads to varied intermolecular distance of Nvjp-1, and mutable stiffness/modulus of Nvjp-1 can be achieved through pH.
•  Work involved managing several inter-disciplinary research projects and serving as a journal referee for PLoS ONE and Biomacromolecules.

National Taiwan University, Department of Civil Engineering

Research Assistant | September 2008 – June 2010

Advisor: Chuin-Shan Chen

• Developed a multi-scale scheme to predict the deformation of the cantilever-beam based biosensor from the atomistic information of self-assembly monolayer adsorption through density-function theory analysis. Results combined macroscopic mechanics theory and the phenomena in microscale and opened an opportunity to investigate in the mechanism of protein adsorbing on cantilever-based biosensor.
• Collaborated with the members of an international research group, Professor Hartmut Schneider and Professor Reinhard X. Fischer, conducting a series of research on mullite, an alumininosilicate material. Deciphered the fundamental mechanism responsible for compositional lattice variations of mullite using molecular dynamics simulations and density-function theory analysis.

Research interests: Computational Mechanics and Materials, Research interests: Computational Mechanics and Materials,Biomechanics, Mechanobiology, Atomic Scale Modeling, Multi-scale/Multi-physicsModeling, Clinical Decision Support, Bioinformatics.

Programming: C++, MS SQL, R, Python, MatLab, High performancecomputing

Software: LAMMPS, CHARMM, GROMACS, QUANTUM ESPRESSO, NAMD, VMD, VASP, TABLEAU

• Shortlisted participant in Asian Deans’ Forum 2018 – The Rising StarsShortlisted participant in Asian Deans’ Forum 2018 – The Rising StarsWomen in Engineering Workshop (2018)
• BTH Fellowship for Digital Healthcare Program at Massachusetts GeneralHospital and Entrepreneur Development Program at MIT Sloan (2017)
• Nominated “Best Poster” at MRS Fall conference, Boston, MA, USA (2013)NSF Fellowship for Cancer Nanotechnology Summer Institute (2011)
• Schoettler Fellowship, MIT (2010)
• Nominated and award a travel grant to attend the workshop on MesoscaleMechanics of Complex Materials (MMCM) (2009)
• 3Scholarship of Chinese Society of Structural Engineering (2005)
• Scholarship of Schoolfellow Association, Department of Civil Engineering,National Taiwan University (2005)
• Award of Outstanding Student in National Taiwan University (2004)
• Award of Outstanding Student in National Taiwan University (2003)

1. C.-C. Chou, F. J. Martin-Martinez, Z. Qin, P. Dennis, R. Naik, and M. J. 1. C.-C. Chou, F. J. Martin-Martinez, Z. Qin, P. Dennis, R. Naik, and M. J.Buehler, “Ion effect and metal-coordinated cross-linking for multiscale design of Nereis jaw inspired mechanomutable materials,” ACS Nano 11, 2017 (IF= 13.942)
2. C.-C. Chou, E. Lepore, P. Antonaci, N. Pugno, and M. J. Buehler, “Mechanics of trichocyte alpha-keratin fibers: Experiment, theory, and simulation,” Journal of Materials Research 30(01): 26-35., 2015 (IF=1.673)
3. C.-C. Chou, M.J. Buehler, “Molecular mechanics of disulfide bonded alpha-helical protein filaments,” BioNanoScience, Vol. 3, 2013 (IF=1.52)
4. C.S. Chen, C.-C. Chou, S.W. Chang, Multiscale analysis of adsorption-inducedsurface stress of alkanethiol on microcantilever, J. Phys. D: Appl. Phys., 46, 2013 (cover image) (IF=2.588)
5. C.-C. Chou, M.J. Buehler, “Structure and mechanical properties of human keratin intermediate filament protein,” Biomacromolecules, Vol. 13(11), 2012 (IF=5.246)
6. S. Keten, C.-C. Chou, A. C.T. van Duin, M.J. Buehler, "Tunable Nanomechanics of Protein Disulfide Bonds in Redox Microenvironments," Journal of the Mechanical Behavior of Biomedical Materials, Vol. 5, 2012 (IF=3.11)
7. C.-C. Chou, M.J. Buehler, “Breaking out of the cage,” Nature Chemistry, Vol. 3(11), pp. 837-839, 2011 (IF=25.87)
8. Z. Qin, C.-C. Chou, L. Kreplak, M.J. Buehler, “Structural, Mechanical and Functional Properties of Intermediate Filaments from the Atomistic to the Cellular Scales.” In: Li S., Sun B. (eds) Advances in Cell Mechanics. Springer, Berlin, Heidelberg, 2011
9. C.-C. Chou, M.J. Buehler, “Bond energy effects on strength and robustness of molecular structures,” Interface Focus, 1(5), 734-743, 2011 (IF=2.693)
10. C.-S. Chen, S. Kuan, T.-H. Chang, C.-C. Chou, L.-S. Huang, “Microcantilever biosensor: sensing platform, surface characterization, and multiscale modeling,” Smart Structures and Systems, 8(1):17-37 2011 (invited). (IF=1.382)
11. C.-S. Chen, C.-C. Chou, S.-W. Chang, R.X. Fischer, H. Schneider,C.-S. Chen, C.-C. Chou, S.-W. Chang, R.X. Fischer, H. Schneider, “First-Principles Study on Variation of Lattice Parameters of Mullite Al₄+_2xSi_2-2xO₁₀-x (x=0.125, 0.250, 0.375),” American Mineralogist, 95, 1617–1623, 2010 (IF=2.204)
12. J.-C. Chen, C.-S. Chen, H. Schneider, C.-C. Chou, and W.-C. J. Wei, J.-C. Chen, C.-S. Chen, H. Schneider, C.-C. Chou, and W.-C. J. Wei,“Atomistic Calculations of Lattice Constants of Mullite with Its Compositions,” Journal of the European Ceramic Society, Vol. 28(2), 345–351, 2008 (IF=3.411)