教授           國立臺灣大學應用力學研究所 
副研發長    國立臺灣大學研究發展處
主任           國立臺灣大學產學合作總中心
主任           國立臺灣大學創新育成中心
主席           Washington Accord
副秘書長/   中華工程教育學會IEET
副執行長  

• 流體力學導論
• 科技研究方法論
• 微流體力學導論
• Technical Communication and Writing

• Teaching Excellence Award, National Taiwan University
• Innovative Award, Institute for Biotechnology and Medical Industry
• Best paper award, Biomedical Engineering Conference, Taipei, Taiwan
• Hiwin Masters’ Thesis Research Award, Hiwin Cooperation
• Research Excellence award, National Science Council, Taiwan

My research focuses on innovative medical device to detect and analyze rare cells in blood, e.g. circulating tumor cells (CTC) as culprit of metastasis causing 90% of cancer death. Collaboration with physicians in breast, colorectal and prostate cancers in NTU Hospital, a 2200-bed facility, ensures yielding focus on clinical utility throughout the development process. 

A) Refereed Papers: (* corresponding author)

1. Chih-Chi Li, Wei-Fan Hsu, Po-Chieh Chiang, Ming-Che Kuo, Andrew M Wo, Yufeng Jane Tseng*. “Characterization of markers, functional properties, and microbiome composition in human gut-derived bacterial extracellular vesicles,” Gut Microbes. 2023 Dec;15(2):2288200.
2. Shin-Yu Lin, Li-Kuo Lu, Wei-Fan Hsu, Wei-Chieh Peng, Hua-Wei Tseng, Chih-Chi Li, Chen-Lin Chen, Guan-Syuan Huang, Chien-Nan Lee, Andrew M Wo*, “A Systemic Approach to Isolate, Retrieve, and Characterize Trophoblasts from the Maternal Circulation Using a Centrifugal Microfluidic Disc and a Multiple Single-Cell Retrieval Strategy,” Anal. Chem. 2023 Feb 14;95(6):3274-3282.
3. Li CC, Hsu WF, Wo AM*. “Exosomes – Potential for Blood-Based Marker in Alzheimer's Disease,” Acta Neurol Taiwan. 2022 Jan 25;31(1):1-6.
4. Kuo CT, Chen CL, Li CC, Huang GS, Ma WY, Hsu WF, Lin CH, Lu YS, Wo AM*., “Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models,” Sci Rep. 2019 Jul 29;9(1):10898. doi: 10.1038/s41598-019-45319-4.
5. Kuo CT, Wang JY, Lu SR, Lai YS, Chang HH, Hsieh JT, Wo AM, Chen BPC, Lu JH, Lee H., “A nanodroplet cell processing platform facilitating drug synergy evaluations for anti-cancer treatments,” Scientific Report. 2019 Jul 12;9(1):10120.
6. Kuo CT, Lu SR, Chen WM, Wang JY, Lee SC, Chang HH, Wo AM*, Chen BPC*, Lee H*., “Facilitating tumor spheroid-based bioassays and in vitro blood vessel modeling via bioinspired self-formation microstructure devices,” Lab Chip. 2018 Aug 7;18(16):2453-2465. doi: 10.1039/c8lc00423d.
7. Ching-Te Kuo, Jong-Yueh Wang, Yu-Fen Lin, Andrew M. Wo, Benjamin P. C. Chen* & Hsinyu Lee*, “Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array,” Scientific Report, 7, Article number: 4363 (2017), doi:10.1038/s41598-017-04718-1
8. Ching-Te Kuo, Jong-Yueh Wang, Andrew M. Wo, Benjamin P. C. Chen and Hsinyu Lee, “ParaStamp and Its Applications to Cell Patterning, Drug Synergy Screening, and Rewritable Devices for Droplet Storage”, Advanced BioSystems, doi/10.1002/adbi.201700048, 2017.
9. Ching-Te Kuo, Cheng-Yu Chi, Pei-Yi Wu, Fang-Tzu Chuang, Yueh-Chien Lin, Hao-Kai Liu, Guan-Syuan Huang, Tzu-Ching Tsai, Andrew M. Wo, Hsinyu Lee and Si-Chen Lee*, “Observation of "wired”cell communication over 10-mm and 20-mm poly(dimethylsiloxane) barriers in tetracycline inducible expression systems,” Appl. Phys. 119, 024702, 2016.
10. Wei-Yuan Ma, Lo-Chang Hsiung, Chen-Ho Wang, Chi-Ling Chiang, Ching-Hung Lin, Chiun-Sheng Huang* and Andrew M. Wo*, “A Novel 96well-formatted Micro-gap Plate Enabling Drug Response Profiling on Primary Tumour Samples,” Scientific Report, 5:9656, DOI: 10.1038/srep09656, 2015. (SCI 5.078)
11. Ching-Te Kuo, Fang-Tzu Chuang, Pei-Yi Wu, Yueh-Chien Lin, Hao-Kai Liu, Guan-Syuan Huang, Tzu-Ching Tsai, Cheng-Yu Chi, Andrew M. Wo, Hsinyu Lee and Si-Chen Lee*, “Experimental demonstration of bindingless signal delivery in human cells via microfluidics,” J Applied Physics, 116, 044702, 2014. (SCI 2.185)
12. Ching-Te Kuo, Chi-Ling Chiang, Chi-Hao Chang, Hao-Kai Liu, Guan-Syuan Huang, Ruby Yun-Ju Huang, Hsinyu Lee*, Chiun-Sheng Huang*, and Andrew M. Wo*, “Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics,”Biomaterials, 2014 Feb; 35(5):1562-71. (8.312)
13. Ching-Te Kuo, Hao-Kai Liu, Guan-Syuan Huang, Chi-Hao Chang, Chen-Lin Chen, Ken-Chao Chen, Ruby Yun-Ju Huang, Ching-Hung Lin, Hsinyu Lee*, Chiun-Sheng Huang* and Andrew M. Wo*, “A spatiotemporally defined in vitro microenvironment for controllable signal delivery and drug screening,” Analyst, 2014,139, 4846-4854
14. Yu-An Chen, Ken-Chao Chen, Vincent F.S. Tsai, Zi-Wei Huang, Ju-Ton Hsieh and Andrew M. Wo*, “Direct Characterization of Motion-Dependent Parameters of Sperm in a Microfluidic Device: Proof of Principle,” Clinical Chemistry (Journal Cover), v. 59, p.493-501, 2013. (SCI 6.3)
15. Chang-Yu Chen, Tsun-Chao Chiang, Cheng-Ming Lin, Shu-Sheng Lin, De-Shien Jong, Vincent F.-S. Tsai, Ju-Ton Hsieh, and Andrew M. Wo, “Sperm Quality Assessment via Separation and Sedimentation in a Microfluidic Device Disk Sperm,” Analyst, 138 (17), 4967 – 4974, 2013. (SCI 4.23)
16. Ting-Yuan Tu, Chang-Yu Chen, De-Shien Jong*, Andrew M. Wo*, “An Integrated Electrophysiological and Optical Approach for Ion Channel Study in a Microfluidic System Enabling Intra- and Extra-cellular Solution Exchange,” Sensors & Actuators: B. Chemical (185), pp. 496-503, 2013.
17. Ching-Te Kuo, Chi-Ling Chiang, Ruby Yun-Ju Huang, Hsinyu Lee and Andrew M Wo*, “Configurable 2D and 3D spheroid tissue cultures on bioengineered surfaces with acquisition of epithelial–mesenchymal transition characteristics,” Nature Asia Materials (2012) 4, e27; doi:10.1038/am.2012.50, 2012. (SCI 9.04)
18. Chang-Yu Chen, Andrew M. Wo* and De-Shien Jong*, “A Microfluidic Concentration Generator for Dose-Response Assays on Ion Channel Pharmacology,” Lab Chip, 12 (4), 794 – 801, 2012. (SCI 6.3)
19. Ken-Chao Chen, Yu-Cheng Pan, Chen-Lin Chen, and Andrew M. Wo*, “Enumeration and viability of rare cells in a microfluidic disk via positive selection approach,” Analytical Biochemistry, 429( 2), 116-123, 2012. (SCI 3.2)
20. Ken-Chao Chen, Tai-Ping Lee, Yu-Cheng Pan, Chi-Ling Chiang, Chen-Lin Chen, Yao-Hsu Yang, Bor-Luen Chiang, Hsinyu Lee, Andrew M. Wo*, “Detection of Circulating Endothelial Cells via a Microfluidic Disk,” Clinical Chemistry, 57: 586-592, 2011. (SCI 6.3)
21. Chen-Lin Chen, Ken-Chao Chen, Yu-Cheng Pan, Tai-Ping Lee, Lo-Chang Hsiung, Cheng-Ming Lin, Chang-Yu Chen, Ching-Hung Lin, Bor-Luen Chiang and Andrew Wo*, “Separation and Detection of Rare Cells in a Microfluidic Disk via Negative Selection,” Lab Chip, 11, 474-483, 2011. (SCI 6.3)
22. Chang-Yu Chen, Ting-Yuan Tu, De-Shien Jong and Andrew M. Wo*, “Ion Channel Electrophysiology via Integrated Planar Patch-clamp Chip with On-demand Drug Exchange,” Biotechnology & Bioengineering, 108, 6, 1395-1403, 2011. (SCI 3.4)
23. Cheng-Ming Lin, Hsin-Ping Liu, Yu-Shiang Lai, Chan-Chia Tseng, Chang-Yu Chen, and Andrew M. Wo*, “Micromixing via Recirculatory Flow Generated by an Oscillatory Microplate,” Microfluid Nanofluid, 11 (2), 167-176, 2011. (SCI 3.3)
24. Lo-Chang Hsiung, Chi-Ling Chiang, Chen-Ho Wang, Yu-Hsu Huang, Ching-Te Kuo, Ji-Yen Cheng, Ching-Hung Lin, Victoria Wu, Hsien-Yeh Chou, De-Shien Jong, Hsinyu Lee,* and Andrew M. Wo*, “Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments,” Lab Chip, 11, 2333–2342, 2011. (SCI 6.3)
25. Chang-Yu Chen, Chang-Hung Chen, Ting-Yuan Tu, Cheng-Ming Lin, and Andrew M. Wo*, “Electrical isolation and characteristics of permanent magnet-actuated valves for PDMS microfluidics”, Lab Chip, 11 (4), 733 – 737, 2011. (SCI 6.3)
26. An-Bang Wang*, Chia-Wei Cheng, I-Chun Lin, Fei-Yau Lu, Huai-Jen Tsai, Chiu-Chun Lin, Chun-Hui Yang, Po-Ting Pan, Chen-Chi Kuan, Yen-Chih Chen, Yi-Wei Lin, Chih-Ning Chang, Yi-Hung Wu, Tetuko Kurniawan, Chii-Wann Lin, Andrew M. Wo, Lin-Chi Chen, “A Novel DNA Selection and Direct Extraction Process and its Application in DNA Recombination,” Electrophoresis, 32(3-4), 423-430, 2011. (SCI 3.1)
27. Yu-An Chen, Zi-Wei Huang, Fang-Sheng Tsai, Chang-Yu Chen, Cheng-Ming Lin and Andrew M. Wo*, “Analysis of sperm concentration and motility in a microfluidic device,” Microfluid Nanofluid, Volume 10, Number 1, 59-67, 2011. (SCI 3.3)
28. Lei*, C.W. Huang, James Chen, C.Y. Yang, Y.J. Lo, Andrew Wo, C.F. Chen and T.W. Fung, “A travelling wave dielectrophoretic pump for blood delivery,” Lab Chip, 9, 1349–1356, 2009. (SCI 6.5)
29. Chang-Yu Chen, Ting-Yuan Tu, Chang-Hung Chen, De-Shien Jong* and Andrew M. Wo*, “Patch clamping on plane glass—fabrication of hourglass aperture and high-yield ion channel recording,” Lab Chip, 9, 2370-2380, 2009. (SCI 6.5)
30. Cheng Ming Lin, Yu Shang Lai, Hsin Ping Liu, Chang Yu Chen, and Andrew M. Wo*, “Trapping of Bioparticles via Microvortices in a Microfluidic Device for Bioassay Applications,” Analytical Chemistry, Vol. 80, pp. 8937-8945, 2008. (SCI 5.287)
31. Cheng Ming Lin, Yu Shang Lai, Hsin Ping Liu, Andrew M. Wo*, “Microvortices and Recirculating Flow Generated by an Oscillatory Microplate for Microfluidic Applications” Applied Physics Letters, Vol. 93, Issue 13, 133503, 2008. (SCI 3.596)
32. Lo-Chang Hsiung, Chun-Hui Yang, Chi-Li Chiu, Chen-Lin Chen, Yueh Wang, Hsinyu Lee, Ji-Yen Cheng, Ming-Chih Ho, Andrew M. Wo*, “A planar interdigitated ring electrode array via dielectrophoresis for uniform patterning of cells,” Biosensors & Bioelectronics, Vol. 24, Issue 4, pp. 869-875, 2008. (SCI 5.061)

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