Self-assembled human arteriole-on-a-chip for arterial functionality testing and disease modeling Selected as the Inside Cover of the Lab-on-a-Chip Journal.

Dr. Yu-Hsiang Hsu’s team developed the first microphysiological system that can stimulate arteriogenesis on a chip and applied this physiological process to develop arterioles on a chip. This system introduces a high oscillating shear flow at 1 Hz in a perfused vessel network. It is demonstrated that the larger vessels enlarged to become primary arteriole vessels, and the smaller vessels were thinned or regressed. Dr. Hsu’s team also demonstrated that the developed arterioles can perform vasoconstrictions and vasodilations, and they also demonstrated that this system can perform arterial thrombosis as a disease model.

Full article link:
Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit.
Lab Chip, 2025, 25, 5162-5179. DOI: 10.1039/D5LC00530B