Job Title:Associate Professor


E-mail:ccchouiam.ntu.edu.tw
Tel:02-33665639
Office:Room421
Lab:Computational Mechanics and Intelligence Lab
Website: https://sites.google.com/g.ntu.edu.tw/ccchou/

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Doctor of Philosophy, 2013
Institute of Applied Mechanics, College of Engineering
National Taiwan University, Taipei, Taiwan
 
Master of Science, 2008
Institute of Biomedical Engineering, College of Medicine and College of Engineering
National Taiwan University, Taipei, Taiwan
 
Bachelor of Science, 2006
Department of Mechanical Engineering, College of Engineering
National Taiwan University, Taipei, Taiwan

National Taiwan University, Center of Innovation and Synergy for Intelligent Home and Living Technology

Postdoctoral Researcher | September 2018

Massachusetts General Hospital, Laboratory of Computer Science

Research Scholar | September 2017 – August 2018

  • Design a risk model to link diagnosis, medical treatment and outcome based on MGH Epic EHR system and MIMIC database.
  • Develop a cognitive aid for clinicians to identify patients at risk of missed or delayed diagnosis, leveraging artificial intelligence technology including natural language processing.

KPMG, Financial Risk Management

Assistant Manager | August 2015 – August 2017

  • Design Asset-Liability-Risk management system, including the spec of a complete data warehouse, ETL, batch and web-based graphic interface, coordinating with Risk-IT teams, financial engineers, and financial managers.
  • Lead finance product valuation team, providing valuation services to clients, developing valuation tools, assisting our company’s audit team.
  •  Played key roles in FRM for developing new projects for future use.
  •  Managed projects with customers’ high satisfaction.

MIT, Department of Civil and Environmental Engineering

Research Assistant | September 2010 – June 2015

Advisor: Markus Buehler

  •   Developed multiscale and theoretical model to link the atomistic chemical structure and macroscopic properties of trichocyte keratin protein, and investigating the mutability of Nvjp-1 protein in various environments using molecular dynamics simulation.
  •  Completed the first full-atomistic model for trichocyte keratin protein and validated the geometrical properties against experimental data. Results of mechanical testing suggested the trichocyte keratin has a higher durability and resistibility against the external loading in the presence of disulfide cross-link.
  •  Investigated the mutability of Nvjp-1 protein with metal-coordination bonds in the varied chemical environments from the single molecule level to a larger length scale. Nvjp-1 forms a more compact structure and metal-coordination in the presence of Zn ions and at a higher pH at the single molecular level. At the mesoscale level, the effect of pH leads to varied intermolecular distance of Nvjp-1, and mutable stiffness/modulus of Nvjp-1 can be achieved through pH.
  •  Work involved managing several inter-disciplinary research projects and serving as a journal referee for PLoS ONE and Biomacromolecules.

National Taiwan University, Department of Civil Engineering

Research Assistant | September 2008 – June 2010

Advisor: Chuin-Shan Chen

  • Developed a multi-scale scheme to predict the deformation of the cantilever-beam based biosensor from the atomistic information of self-assembly monolayer adsorption through density-function theory analysis. Results combined macroscopic mechanics theory and the phenomena in microscale and opened an opportunity to investigate in the mechanism of protein adsorbing on cantilever-based biosensor.
  • Collaborated with the members of an international research group, Professor Hartmut Schneider and Professor Reinhard X. Fischer, conducting a series of research on mullite, an alumininosilicate material. Deciphered the fundamental mechanism responsible for compositional lattice variations of mullite using molecular dynamics simulations and density-function theory analysis.

 

Research interests: Computational Mechanics and Materials, Research interests: Computational Mechanics and Materials,Biomechanics, Mechanobiology, Atomic Scale Modeling, Multi-scale/Multi-physicsModeling, Clinical Decision Support, Bioinformatics.

Programming: C++, MS SQL, R, Python, MatLab, High performancecomputing

Software: LAMMPS, CHARMM, GROMACS, QUANTUM ESPRESSO, NAMD, VMD, VASP, TABLEAU

  • Shortlisted participant in Asian Deans’ Forum 2018 – The Rising StarsShortlisted participant in Asian Deans’ Forum 2018 – The Rising StarsWomen in Engineering Workshop (2018)
  • BTH Fellowship for Digital Healthcare Program at Massachusetts GeneralHospital and Entrepreneur Development Program at MIT Sloan (2017)
  • Nominated “Best Poster” at MRS Fall conference, Boston, MA, USA (2013)NSF Fellowship for Cancer Nanotechnology Summer Institute (2011)
  • Schoettler Fellowship, MIT (2010)
  • Nominated and award a travel grant to attend the workshop on MesoscaleMechanics of Complex Materials (MMCM) (2009)
  • 3Scholarship of Chinese Society of Structural Engineering (2005)
  • Scholarship of Schoolfellow Association, Department of Civil Engineering,National Taiwan University (2005)
  • Award of Outstanding Student in National Taiwan University (2004)
  • Award of Outstanding Student in National Taiwan University (2003)
  1. C.-C. Chou, F. J. Martin-Martinez, Z. Qin, P. Dennis, R. Naik, and M. J. 1. C.-C. Chou, F. J. Martin-Martinez, Z. Qin, P. Dennis, R. Naik, and M. J.Buehler, “Ion effect and metal-coordinated cross-linking for multiscale design of Nereis jaw inspired mechanomutable materials,” ACS Nano 11, 2017 (IF= 13.942)
  2. C.-C. Chou, E. Lepore, P. Antonaci, N. Pugno, and M. J. Buehler, “Mechanics of trichocyte alpha-keratin fibers: Experiment, theory, and simulation,” Journal of Materials Research 30(01): 26-35., 2015 (IF=1.673)
  3. C.-C. Chou, M.J. Buehler, “Molecular mechanics of disulfide bonded alpha-helical protein filaments,” BioNanoScience, Vol. 3, 2013 (IF=1.52)
  4. C.S. Chen, C.-C. Chou, S.W. Chang, Multiscale analysis of adsorption-inducedsurface stress of alkanethiol on microcantilever, J. Phys. D: Appl. Phys., 46, 2013 (cover image) (IF=2.588)
  5. C.-C. Chou, M.J. Buehler, “Structure and mechanical properties of human keratin intermediate filament protein,” Biomacromolecules, Vol. 13(11), 2012 (IF=5.246)
  6. S. Keten, C.-C. Chou, A. C.T. van Duin, M.J. Buehler, "Tunable Nanomechanics of Protein Disulfide Bonds in Redox Microenvironments," Journal of the Mechanical Behavior of Biomedical Materials, Vol. 5, 2012 (IF=3.11)
  7. C.-C. Chou, M.J. Buehler, “Breaking out of the cage,” Nature Chemistry, Vol. 3(11), pp. 837-839, 2011 (IF=25.87)
  8. Z. Qin, C.-C. Chou, L. Kreplak, M.J. Buehler, “Structural, Mechanical and Functional Properties of Intermediate Filaments from the Atomistic to the Cellular Scales.” In: Li S., Sun B. (eds) Advances in Cell Mechanics. Springer, Berlin, Heidelberg, 2011
  9. C.-C. Chou, M.J. Buehler, “Bond energy effects on strength and robustness of molecular structures,” Interface Focus, 1(5), 734-743, 2011 (IF=2.693)
  10. C.-S. Chen, S. Kuan, T.-H. Chang, C.-C. Chou, L.-S. Huang, “Microcantilever biosensor: sensing platform, surface characterization, and multiscale modeling,” Smart Structures and Systems, 8(1):17-37 2011 (invited). (IF=1.382)
  11. C.-S. Chen, C.-C. Chou, S.-W. Chang, R.X. Fischer, H. Schneider,C.-S. Chen, C.-C. Chou, S.-W. Chang, R.X. Fischer, H. Schneider, “First-Principles Study on Variation of Lattice Parameters of Mullite Al4+2xSi2-2xO10-x (x=0.125, 0.250, 0.375),” American Mineralogist, 95, 1617–1623, 2010 (IF=2.204)
  12. J.-C. Chen, C.-S. Chen, H. Schneider, C.-C. Chou, and W.-C. J. Wei, J.-C. Chen, C.-S. Chen, H. Schneider, C.-C. Chou, and W.-C. J. Wei,“Atomistic Calculations of Lattice Constants of Mullite with Its Compositions,” Journal of the European Ceramic Society, Vol. 28(2), 345–351, 2008 (IF=3.411)

and functional ankle instability for inversion ankle sprain patients. Journal of science and medicine in sport18(2), 128-132.

  • Lin, C. Y., Shau, Y. W., Wang, C. L., Chai, H. M., & Kang, J. H. (2013). Quantitative evaluation of the viscoelastic properties of the ankle joint complex in patients suffering from ankle sprain by the anterior drawer test. Knee Surgery, Sports Traumatology, Arthroscopy21(6), 1396-1403.
  • Chen, G. S., Lin, C. Y., Jeong, J. S., Cannata, J. M., Lin, W. L., Chang, H., & Shung, K. (2012). Design and characterization of dual-curvature 1.5-dimensional high-intensity focused ultrasound phased-array transducer. IEEE transactions on ultrasonics, ferroelectrics, and frequency control59(1).

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TEL : 886-2-3366-5600
FAX : 886-2-2363-9290
Address : 106 No.1, Sec. 4, Roosevelt Rd., Da’an Dist., Taipei City 106, Taiwan (R.O.C.) Institute of Applied Mechanics, National Taiwan University

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